The Ultimate Cassiopeia Bot/APC Guide (Latest Patch) - Slither, Sizzle, and Scale your way to the top!

With this ultimate Cassiopeia bot/APC guide you will start dominating your enemies and start ranking up! 

Cassiopeia Bot/APC Runes:

Primary: Precision

Keystone: Conqueror

Presence of Mind

Legend: Tenacity

Coup de Grace

Secondary: Resolve

Conditioning

Overgrowth

Stat Shards:

+9 Adaptive (5.4 AD or 9 AP)

+9 Adaptive (5.4 AD or 9 AP)

+8 Magic Resist

Cassiopeia Bot/APC Summoner Spells:

Flash

Ignite

Cassiopeia Items to buy:

Cassiopeia Starting Items:

Doran's Ring, Tear of the Goddess, Health Potion x2, or Corrupting Potion

Cassiopeia Full Build:

Seraph's Embrace, Rylai's Crystal Scepter, Zhonya's Hourglass, Liandry's Anguish, Morellonomicon, Demonic Embrace, Stealth Ward

Cassiopeia - Ability Skill Order:

Q (Noxious Blast): 2, 8, 10, 12, 13

W (Miasma): 3, 14, 15, 17, 18

E (Twin Fang): 1, 4, 5, 7, 9

R (Petrifying Gaze): 6, 11, 16

General Playstyle as Cassiopeia bot/APC:

Cassiopeia Bot/APC Laning Phase:

Trade efficiently, focusing on short trades due to her initial low mana pool. Use Q when enemies go for CS and manage your wave to avoid ganks. Once Tear is acquired, you can be more aggressive with your mana usage.

Cassiopeia Bot/APC Mid Game:

With Seraph's Embrace and Rylai's, play aggressively. Cassiopeia's damage is significant during this phase. Assist with objectives, especially dragons.

Cassiopeia Bot/APC Late Game:

Cassiopeia becomes a powerhouse. Stick with the team, look for opportunities to land a multi-target ultimate, and control objectives.

Teamfighting as Cassiopeia BOT:

Stay in the backline, consistently applying poison and spamming E. Use W to control enemy movement and look for a good opportunity to use your ultimate, either for a multi-target stun or to peel for yourself.

Dragon and Baron Fights as Cassiopeia:

Cassiopeia can shred through objectives like Dragon and Baron due to her consistent DPS. Ensure vision control and use her Miasma (W) to zone out enemies.

Cassiopeia - Matchups:

Bad Matchup: Heimerdinger was mentioned as an extreme threat. Cassiopeia struggles against champions that can push her in and poke her from a distance.

Good Matchups: Specific champions weren't mentioned, but Cassiopeia generally does well against immobile mages and champions she can kite.

Synergies:

The data didn't specify champions that synergize well with Cassiopeia in the bot lane. However, champions with crowd control or peel can help her maximize her damage output.

Enjoy this ultimate Cassiopeia Bot/APC guide (latest patch, 13.16).